Publications

1. Yang J, Zoeller RT. (2002). Differential display identifies neuroendocrine-specific protein-A (NSP-A) as an ethanol-responsive gene in the fetal rat brain. Brain Res Dev Brain Res138, 117-133.
2. Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T. (2002). Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. J Cell Biol159, 431-440.
3. Hong D, Pawlyk B, Sokolov M, Strissel KJ, Arshavsky VY, Yang J, Tulloch B, Wright AF, Li T. (2003). RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. Invest Ophthalmol Vis Sci44, 2413-2421.
4. Liu X, Bulgakov O, Wen X, Woodruff ML, Pawlyk B, Yang J, Fain GL, Sandberg MA, Makino CL, Li T. (2004). AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. Proc Natl Acad Sci U S A101, 13903-13908.
5. Yang J, Li T. (2005). The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res309, 379-389.
6. Yang J, Gao J, Adamian M, Wen X, Pawlyk B, Zhang L, Sanderson MJ, Zuo J, Makino CL and Li T. (2005). The ciliary rootlet maintains long-term stability of the sensory cilia. Mol Cell Biol25, 4129-4137.
7. Yang J, Adamian M, Li T. (2006). Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells. Mol Biol Cell17, 1033-1040.
8. Yang J, Pawlyk B, Wen X, Adamian M, Soloviev M, Michaud N, Zhao Y, Sandberg, MA, Makino CL, Li T. (2007). Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Hum Mol Genet16, 1017-1029.
9. Yang J, Li T. (2006). Rootletin. [Review]. Exp Eye Res83, 1-2.
10. Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC and Li T. (2010). Ablation of Whirlin Long Isoform Disrupts the USH2 Protein Complex and Causes Vision and Hearing Loss. PLoS Genet6(5), e10000955.
11. Zou J, Luo L, Shen Z, Choido V, Ambati BK, Hauswirth WW, Yang J. (2011). Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors. Invest Ophthalmol Vis Sci52, 2343-2351.
12. Yang J, Wang L, Song H, and Sokolov M. (2012). Current Understanding of Usher Syndrome Type II. [Review]. Frontiers in Bioscience17, 1165-1183.
13. Yang J. (2012). Usher Syndrome: Genes, Proteins, Models, Molecular Mechanisms, and Therapies.  Hearing Loss, Dr. Sadaf Naz (Ed.), ISBN: 978-953-51-0366-0, Intech.
14. Wang L, Zou J, Shen Z, Song E, Yang J. (2012). Whirlin interacts with espin and modulates its actin-regulatory function: an insight into the mechanism of Usher syndrome type II. Hum Mol Genet, 21, 692-710.
15. Zou J, Lee A, Yang J. (2012). The expression of whirlin and Ca(v)1.3alpha(1) is mutually independent in photoreceptors.Vision Res, 75, 53 - 59.
16. Green JA, Yang J, Grati M, Kachar B, Bhat MA. (2013). Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons. BMC Neurosci, 14, 96.
17. Zou J, Zheng T, Ren C, Askew C, Liu X, Pan B, Holt JR, Wang Y, Yang J. (2014). Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Hum Mol Genet, 23, 2374-2390.
18. Chen Q, Zou J, Shen Z, Zhang W, Yang J. (2014). Whirlin and PDZ domain containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2. J Biol Chem, 289, 36070-36088.
19. Mathur P, Yang J. (2015). Usher syndrome: hearing loss, retinal degeneration and associated abnormalities. BBA-Molecular Basis of Disease, 1852, 406-420.
20. Mathur PD, Zou J, Zheng T, Almishaal A, Wang Y, Chen Q, Wang L, Vashist D, Brown S, Park A, Yang J. (2015). Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31. Hum Mol Genet, 24, 6213-6228.
21. Zou J, Mathur PD, Zheng T, Wang Y, Almishaal A, Park AH, Yang J. (2015). Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle. Hum Mol Genet, 24, 24, 6944-6957.
22. Mathur PD, Vijayakumar S, Vashist D, Jones SM, Jones TA, Yang J. (2015). A study of whirlin isoforms in the mouse vestibular system suggests potential vestibular dysfunction in DFNB31-deficient patients. Hum Mol Genet, 24, 7017-7030.
23. Ciardo MG, Andres-Borderia A, Cuesta N, Valente P, Camprubi-Robles M, Yang J, Planells-Cases R, Ferrer-Montiel A (2016). Whirlin increases TRPV1 channel expression and cellular stability. Biochim Biophys Acta, 1863(1), 115-127.
24. Zou J, Chen Q, Almishaal A, Mathur PD, Zheng T, Tian C, Zheng QY, Yang J. (in press). The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells. Hum Mol Genet.